?DISSOCIATION EXTRACTION PROCESS FOR THE SEPARATION OF ISOMERIC ORGANIC COMPOUNDS

Abstract

Separation of mixture of isomeric organic compound was achieved by exploiting the difference in their dissociation
constants by employing dissociation extraction technique. Mixture of 3-picoline and 4-picoline was partially separated
with sodium dihydrogen phosphate to demonstrate the phenomenon of dissociation extraction. A theoretical treatment of
separation of isomers is given which can be utilized to predict the separation factor of dissociated and undissociated species
of isomers. Increase in temperature had a positive influence on the separation of isomers and also on the phase disengagement
between the aqueous and the organic phases. A process is described to develop a suitable chemical material bed in the
column for gas-liquid chromatograph that reduces the retention time and gives high resolution of picolines.